SARS-CoV-2 diversity and transmission on a university campus across two academic years during the pandemic
Castro, et al. 2024
Using multiplexed functional data to reduce the VUS burden in populations underrepresented in genomic medicine
Dawood, et al. 2024
P390: Assessing and addressing the burden of VUSs within adult medical genetics practices
Stergachis, et al. 2024
Defining and Reducing Variant Classification Disparities
Dawood, et al. 2024
Consultation informs strategies to improve functional evidence use in variant classification
Villani, et al. 2024
Scenario projections of RSV hospitalizations averted due to new immunization programs in King County, Washington, October 2023 to May 2025
Hansen, et al. 2024
Tiny swabs: nasal swabs integrated into tube caps facilitate large-scale self-collected SARS-CoV-2 testing
Pfau, Opsahl, et al. 2024
CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods
Claussnitzer, at el. 2024
Utilizing a university testing program to estimate relative effectiveness of monovalent COVID-19 mRNA booster vaccine versus two-dose primary series against symptomatic SARS-CoV-2 infection
Bennet, et al. 2024
Remote surveillance and detection of SARS-CoV-2 transmission among household members in King County, Washington
Emanuels, et al. 2024
Local-scale phylodynamics reveal differential community impact of SARS-CoV-2 in a metropolitan US county
Paredes, et al. 2024
Comparative Diagnostic Utility of SARS-CoV-2 Rapid Antigen and Molecular Testing in a Community Setting
Kim, et al. 2024
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes
Friedman, et al. 2024

Remote Surveillance and Detection of SARS-CoV-2 Transmission Among Household Members in King County, Washington
Rogers, et al. 2022
Local-Scale phylodynamics reveal differential community impact of SARS-CoV-2 in metropolitan US county
Parades, et al. 2022
Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment
Chiou, et al. 2022
1456. Environmental and Nasal Pathogen Surveillance in Seattle Area Homeless Shelters
Franko, et al. 2022
1916. Evaluation of nasal swab collection methods on a university campus during the SARS-CoV-2 pandemic
O'Hanlon, et al. 2022
1359. Human Parainfluenza Epidemiology in Homeless Shelters—King County, Washington
Chow, et al. 2022
Trends in risk factors and symptoms associated with SARS-CoV-2 and rhinovirus test positivity in King County, Washington, June 2020 to July 2022
Hansen, et al. 2022
1904. Health Behavioral Trends and Absenteeism Associated with Acute Respiratory Illness Before and During the SARS-CoV-2 Pandemic in a Community Household Cohort, King County, Washington
Chung, et al. 2022
2202. Influenza Surveillance of Families in an Observational Household Study 2019-2021
Babu, et al. 2022
Human Parainfluenza Virus in Homeless Shelters before and during the COVID-19 Pandemic, Washington, USA
Chow, et al. 2022
SARS-CoV-2 Screening Testing in Schools: A Comparison of School-Vs. Home-Based Collection Methods
Chung, et al. 2022
The clinical and genomic epidemiology of rhinovirus in homeless shelters—King County, Washington
Chow, et al. 2022
A single-cell multi-omic atlas spanning the adult rhesus macaque brain
Chiou, et al. 2022
Genomic surveillance of SARS-CoV-2 Omicron variants on a university campus
Weil, et al. 2022
Multiplex target-redundant RT-LAMP for robust detection of SARS-CoV-2 using fluorescent universal displacement probes
Kline, et al. 2022
Human iPSC Derived Enamel Organoid Guided by Single-Cell Atlas of Human Tooth Development
Alghadeer, et al. 2022
Single-cell analysis of chromatin and expression reveals age-and sex-associated alterations in the human heart
Read, et al. 2022
Associations Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants and Risk of Coronavirus Disease 2019 (COVID-19) Hospitalization Among Confirmed Cases in Washington State: A Retrospective Cohort Study
Paredes, et al. 2022
Simultaneous monitoring of HIV viral load and screening of SARS-CoV-2 employing a low-cost RT-qPCR test workflow
Gulati, et al. 2022
Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context.
Radkov, et al. 2022
Mapping the emergence of SARS-CoV-2 Omicron variants on a university campus
Weil, et al. 2022
The functional impact of BRCA1 BRCT domain variants using multiplexed DNA double-strand break repair assays
Adamovich, et al. 2022
Characterizing neurons in schizophrenia-associated regions of the rhesus macaque brain
Dugan, et al. 2022
Full View Highly sensitive immunoresistive sensor for point-of-care screening for COVID-19
Li, et al. 2022
Substrate topology and cognate immunity modulate antibacterial toxicity of Tae cell wall hydrolases
Radkov, et al. 2022
Interactions among 17 respiratory pathogens: a cross-sectional study using clinical and community surveillance data
Burstein, et al. 2022
Diagnostic accuracy of an at-home, rapid self-test for influenza: prospective comparative accuracy study
Geyer, et al. 2022
Phylogenomics of Severe Acute Respiratory Syndrome Coronavirus 2 in Emergency Shelters for People Experiencing Homelessness
Casto, et al. 2022
MaveDB v2: a curated community database with over three million variant effects from multiplexed functional assays
Rubin, et al. 2022
Human Parainfluenza Epidemiology in Homeless Shelters - King County, Washington
Chow, et al. 2022

The Seattle Flu Study: when regulations hinder pandemic surveillance
Boeckh, et al. 2021
Harmony COVID-19: A ready-to-use kit, low-cost detector, and smartphone app for point-of-care SARS-CoV-2 RNA detection
Panpradist, et al. 2021
Closing the gap: Systematic integration of multiplexed functional data resolves variants of uncertain significance in BRCA1, TP53, and PTEN
Fayer, et al. 2021
Remote Household Observation for Noninfluenza Respiratory Viral Illness
Emanuels, et al. 2021
SwabExpress: An End-to-End Protocol for Extraction-Free COVID-19 Testing
Srivatsan, et al. 2021
SARS-CoV-2 Epidemiology on a Public University Campus in Washington State
Weil, et al. 2021
Incidence of medically attended acute respiratory illnesses due to respiratory viruses across the life course during the 2018/19 influenza season
Jackson, et al. 2021
Inexpensive workflow for simultaneous monitoring of HIV viral load and detection of SARS-CoV-2 infection
Gaurav, et al. 2021
School-Based Surveillance of Respiratory Pathogens on “High-Touch” Surfaces
Murray, et al. 2021
Comparison of symptoms and RNA levels in children and adults with SARS-CoV-2 infection in the community setting
Chung, et al. 2021
Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State
Müller, et al. 2021
Comparable Specimen Collection from Both Ends of At-Home Midturbinate Swabs
Truong, et al. 2021
Evaluating Specimen Quality and Results from a Community-Wide, Home-Based Respiratory Surveillance Study
Kim, et al. 2021
Corrigendum to ‘Simpler and faster Covid-19 testing: Strategies to streamline SARS-CoV-2 molecular assays’
Panpradist, et al. 2021
Effects of weather-related social distancing on city-scale transmission of respiratory viruses: a retrospective cohort study
Jackson, et al. 2021
Simpler and faster Covid-19 testing: Strategies to streamline SARS-CoV-2 molecular assays
Panpradist, et al. 2021
Characteristics of COVID-19 in Homeless Shelters: A Community-Based Surveillance Study
Rogers, et al. 2021

Multiplexed functional assessment of genetic variants in CARD11
Meitlis, et al. 2020
Point-of-care molecular testing and antiviral treatment of influenza in residents of homeless shelters in Seattle, WA: study protocol for a stepped-wedge cluster-randomized controlled trial
Newman, et al. 2020
Viral genome sequencing places White House COVID-19 outbreak into phylogenetic context
Bedford, et al. 2020
Seattle flu study “swab and send”: At-home surveillance methods to estimate the burden of respiratory pathogens on a city-wide scale
Kim, et al. 2020
The Seattle Flu Study: a multiarm community-based prospective study protocol for assessing influenza prevalence, transmission and genomic epidemiology
Chu, et al. 202
Cryptic transmission of SARS-CoV-2 in Washington state
Bedford, et al. 2020
Cross-Sectional Prevalence of SARS-CoV-2 Among Skilled Nursing Facility Employees and Residents Across Facilities in Seattle
Weil, et al. 2020
Early Detection of Covid-19 through a Citywide Pandemic Surveillance Platform
Chu, et al. 2020
Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma
Alexander, et al. 2020
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
Deng, et al. 2020
Evidence for Limited Early Spread of COVID-19 Within the United States, January–February 2020
Jorden, et al. 2020
Preliminary support for a "dry swab, extraction free" protocol for SARS-CoV-2 testing via RT-qPCR
Srivatsan, et al. 2020
COVID-19 SCAN molecular workflow
Starita, 2020
Effects of weather-related social distancing on city-scale transmission of respiratory viruses
Jackson, et al. 2020

Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework
Brnich, et al. 2019
Recommendations for the collection and use of multiplexed functional data for clinical variant interpretation
Gelman, et al. 2019
MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect
Esposito D, Weile J, Shendure J, Starita LM, Papenfuss AT, Roth FP , et al. 2019
A Community-wide Study to Evaluate the Accuracy of Self-testing for Influenza: Works in Progress
Thompson M, Zigman Suchsland ML, Lyon V, Kline E, Huang SC, Chu HY, et al. 2019
The Seattle Flu Study: A Community-Based Study of Influenza
Chu HY, Boeckh M, Englund JA, Famulare M, Lutz BR, Nickerson DA, Rieder M , et al. 2019
Accurate functional classification of thousands of BRCA1 variants with saturation genome editing
Findlay FM, Daza R, Martin BK, Zhang MD, Leith AP, Gasperini M, et al. 2019
An open-source platform to distribute and interpret data from multiplexed assays of variant effect
Esposito D, Weile J, Shendure J, Starita LM, Papenfuss AT, Roth FP, et al. 2019

A multiplex homology-directed DNA repair assay reveals the impact of more than 1,000 BRCA1 missense substitution variants on protein function
Starita LM, Islam MM, Banerjee T, Adamovich Al, Gullingsrud J, Fields S, et al. 2018
Multiplex assessment of protein variant abundance by massively parallel sequencing
Matreyek KA, Starita LM, Stephany JJ, Martin B, Chiasson MA, Gray VE, et al. 2018
A multiplexed homology-directed DNA repair assay reveals the impact of ~1,700 BRCA1 variants on protein function
Starita LM, Islam MM, Banerjee T, Adamovich Al, Gullingsrud J, Fields S, et al. 2018
On the design of CRISPR-based single-cell molecular screens
Hill AJ, McFaline-Figueroa, Starita LM, Gasperini MJ, Matreyek KA, et al. 2018
Using Multiplexed Genome Editing to Distinguish between Loss- and Gain-of-Function Variants in CARD11
James R, Meitlis I, Hung KL, Rawlings DJ, Allenspach EJ, Starita LM. 2017
Variant interpretation: functional assays to the rescue
Starita LM, Ahituv N, Dunham MJ, Kitzman JO, Roth FP, Seelig G, et al. 2017
Massively parallel single-amino-acid mutagenesis
Kitzman JO, Chowdary PD, Gao X, Ci B, Li W, Mulgaonkar A, et al. 2017
Bedside back to bench: building bridges between basic and clinical genomic research
Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, et al. 2017
The power of multiplexed functional analysis of genetic variants
Gasperini M, Starita LM, Shendura J. 2016
Proffered papers and posters presented at the Sixth International Symposium on Hereditary Breast and Ovarian Cancer—BRCA: challenges and opportunities
Starita LM, Islam M, Fields S, Parvin JD, Shendure J. 2016
Highly multiplex single amino acid mutagenesis for massively parallel functional analysis
Shendure J, Fields S, Kitzman J, Starita LM. 2016
Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks
Lee C, Banerjee T, Gillespie J, Ceravolo A, Parvinsmith MR, Starita LM, et al. 2015
Deep Mutational Scanning: Calculating Enrichment Scores for Protein Variants from DNA Sequencing Output Files
Starita LM, Fields S. 2015
Deep mutational scanning: Library construction, functional selection, and high-throughput sequencing
Starita LM, Fields S. 2015
Deep Mutational Scanning: A Highly Parallel Method to Measure the Effects of Mutation on Protein Function
Starita LM, Fields S. 2015

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Starita Lab